[Job-offers-cs] Opening for postdoctoral researcher - cerebrospinal fluid dynamics in the brain - University of Rochester

[Pekka Orponen]

-------- Forwarded Message --------
Subject: 	[SIAM-DY] opening for postdoctoral researcher - cerebrospinal 
fluid dynamics in the brain - University of Rochester
Date: 	Tue, 3 Mar 2020 09:28:39 +0000
From: 	Kelley, Douglas <d.h.kelley at rochester.edu>
To: 	Pekka Orponen <pekka.orponen at aalto.fi>
CC: 	The Dynamical Systems SIAG mailing list <siam-dy at siam.org>


Applications are invited for a postdoctoral researcher to study the 
dynamics of cerebrospinal fluid in the brain at the University of 
Rochester. The work will focus on the fluid dynamics and physical 
mechanisms of the recently-discovered glymphatic system, which 
sweeps away metabolic waste by pumping cerebrospinal fluid through 
the brain during sleep. The glymphatic system likely plays a key role 
both in improving cognitive ability after sleep and in preventing 
diseases such as Alzheimer's that result from waste buildup. The 
successful candidate will address a wide array of open questions: Along 
what paths does fluid flow in the brain? What mechanisms drive its 
motion? How does flow connect to neural activity like slow waves and to 
cognitive ability after sleep? How does flow change during pathological 
conditions such as stroke and traumatic brain injury? How does flow 
change as waste builds up, and do these changes accelerate buildup?

The successful candidate will join a team in the Department of 
Mechanical Engineering, led by Douglas H. Kelley, John H. Thomas, and 
Jessica K. Shang, which has published recent results in /Science/, 
/Nature Communications/, /JCI Insight/, /Journal of the Royal Society: 
Interface/, and elsewhere. We expect to continue publishing high-impact 
discoveries.

The successful candidate will use particle tracking, front tracking, and 
other sophisticated tools to measure cerebrospinal fluid flow from in 
vivo mouse experiments. Experience in programming, analysis of large 
data sets, and fluid dynamics is essential. Experience with particle 
tracking, image analysis, or in vivo/vitro biofluids experiments is a 
plus. Excellent writing skills are preferred. We collaborate closely 
with Maiken Nedergaard at the University of Rochester Medical 
Center, whose team discovered the glymphatic system and performs the in 
vivo experiments (the successful candidate may also have the opportunity 
to engage in experiments). The successful candidate will be encouraged 
to collaborate with others in Mechanical Engineering who study the 
glymphatic system via numerical simulations, theoretical arguments, and 
experiments; currently two other postdoctoral researchers, two PhD 
students, and a few undergraduate researchers are involved, in addition 
to the faculty mentors. More information is available at 
www.me.rochester.edu/projects/dhkelley-lab. We anticipate a 1 July 
2020 start date, but some flexibility is possible. For full 
consideration, applicants should email a curriculum vitae and cover 
letter to d.h.kelley at rochester.edu <mailto:d.h.kelley at rochester.edu> by 
1 April 2020.

Douglas H. Kelley
Associate Professor, Mechanical Engineering, University of Rochester
Visiting Associate Professor, Center for Translational Neuroscience, 
University of Copenhagen
www.me.rochester.edu/projects/dhkelley-lab 
<http://www.me.rochester.edu/projects/dhkelley-lab>